Melanocortin-3-receptor gene variants in morbid obesity
نویسندگان
چکیده
منابع مشابه
The role of melanocortin 3 receptor gene in childhood obesity.
OBJECTIVE Melanocortin 3 receptor (MC3R) plays a critical role in weight regulation of rodents, but its role in humans remains unclear. The objective of this study was to identify genetic variants of the MC3R gene and determine its association with childhood obesity. RESEARCH DESIGN AND METHODS We screened 201 obese children for MC3R gene mutations with anthropometric measurements, blood test...
متن کاملLeptin receptor gene polymorphisms and morbid obesity in Mexican patients
BACKGROUND Human obesity is due to a complex interaction among environmental, behavioral, developmental and genetic factors, including the interaction of leptin (LEP) and leptin receptor (LEPR). Several LEPR mutations and polymorphisms have been described in patients with early onset severe obesity and hyperphagic eating behavior; however, some contradictory findings have also been reported. In...
متن کاملDominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency.
Over 20 severely obese subjects in 11 independent kindreds have been reported to have pathogenic heterozygous mutations in the gene encoding the melanocortin 4 receptor (MC4R), making this the most common known monogenic cause of human obesity. To date, the detailed clinical phenotype of this dominantly inherited disorder has not been defined, and no homozygous subjects have been described. We ...
متن کاملMelanocortin-4 receptor mutations are a frequent and heterogeneous cause of morbid obesity.
By integrating an agonist satiety signal, provided by alpha-melanocyte-stimulating hormone (alpha-MSH), and an antagonist signal, provided by agouti-related protein (AGRP), the melanocortin-4 receptor (MC4-R) is a key element in the hypothalamic control of food intake. Inactivation of the gene encoding this G protein-coupled receptor causes obesity in mice. In humans, frameshift mutations in MC...
متن کاملAssociation of the melanocortin-3(MC3R) receptor gene with growth and reproductive traits in Mazandaran indigenous chicken
Melanocortin-3 receptor (MC3R) plays an important role in the central control of energy homeostasis, and several functional polymorphisms of this gene have been detected. We have studied MC3R as a candidate gene responsible for variation in economically important traits in chicken. To determine the association between MC3R polymorphism and phenotypic variation, a total of 190 individuals from b...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: International Journal of Obesity
سال: 2003
ISSN: 0307-0565,1476-5497
DOI: 10.1038/sj.ijo.0802184